swelling of the eyelids, face, lips, hands, or feet, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site. After 48 weeks, 35% of people who took Fasenra had asthma flare-ups, compared with 51% of people who took a placebo. But if your fever lasts more than 3 days or is higher than 103F (about 39.4C), tell your doctor. Normal levels of eosinophils help your body fight against infections. If you need financial support to pay for Fasenra, or if you need help understanding your insurance coverage, help is available. Note: The Food and Drug Administration (FDA) tracks side effects of drugs they have approved. The exact mechanism of action of Fasenra has not been completely elucidated. Keep in mind that Fasenra isnt a rescue inhaler. The Fasenra site also has some useful resources on using the autoinjector pen. The FDA is currently deciding whether to approve Fasenra for treating nasal polyps. Follow your doctor's orders or the directions on the label. It comes as a metered-dose inhaler. High levels of eosinophils can cause swelling in your airways and lead to severe eosinophilic asthma. Applies to benralizumab: subcutaneous solution. Some drugs may be better suited for you than others. For more information and to find out if youre eligible for support, call 833-360-HELP (833-360-4357) or visit the program website. Fasenra can be kept at room temperature for up to 14 days if necessary. But if you think youre having a medical emergency, you should call 911 or your local emergency number. Clearance of Fasenra is not impacted by renal or hepatic function, age, gender, or race. Talk with your doctor about your health history before you take Fasenra. Some side effects may not be reported. Dupixent (dupilumab) is a prescription drug that comes as an injection. Once administered, Fasenra reaches its absorption half-life within 3.5 days. MNT is the registered trade mark of Healthline Media. Both Fasenra and Nucala (mepolizumab) are prescribed to treat severe eosinophilic asthma in adults and some children. There are currently no biosimilar forms of either drug available. Do not shake. Below are some common questions about taking Fasenra. These side effects may go away during treatment as your body adjusts to the medicine. It also helps keep the drug from harming the environment. Asthma is a condition in which your airways become swollen, making it hard to breathe. Symbicort may interact with antibiotics, antifungal medications, MAO inhibitors, antidepressants, beta-blockers, and . If you have questions about how to pay for your prescription, talk with your doctor or pharmacist. Fasenra works by attaching to eosinophils. Some dosage forms listed on this page may not apply to the brand name Fasenra. Off-label drug use is when a drug thats approved for one condition is used for a different one thats not approved. Asthma is a condition that affects your airways, which are a network of tubes that allow air to move from outside of your body into your lungs. Biosimilars and generics also usually cost less than brand-name drugs. Its not known whether its safe to take Fasenra while pregnant or breastfeeding. There arent any known interactions between Fasenra and alcohol. Pregnancy registries gather data on the safety of using medications such as Fasenra during pregnancy. Gastrointestinal problems. But if your throat pain is severe or lasts more than a few days, tell your doctor. upper respiratory tract infections, abdominal pain, vomiting, diarrhoea, skin rashes, arthritis, muscle aches and joint pain. To learn more, call 877-311-8972 or visit the study website. Below are examples of these side effects. Even though Fasenra and steroids are both used to treat asthma, these drugs work differently in your body. Do not change any other medications, such as reducing your corticosteroid dosage, without talking to your doctor first. Fasenra and Xolair are both brand-name drugs. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Xolair is FDA-approved to treat allergic asthma thats moderate to severe and persistent. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Long-term side effects werent reported in studies of the drug. In clinical studies, sore throat occurred in 5% of people taking Fasenra compared with 3% of people who took a placebo. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. (Conditions or factors that could prevent your doctor from prescribing a medication are called contraindications.) In certain people, Xolair is also approved to treat: Youll use Xolair with your other asthma medications rather than by itself. But allergic reactions to Fasenra are rare. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Do not use this medicine if it is cloudy or if there are particles in it. Fasenra may be used to treat severe eosinophilic asthma and after an initial loading dose, may be self-administered every eight weeks using a Fasenra autoinjector pen. And no long-term side effects have been reported since the drug became available. Separate studies of the two drugs were compared in a larger review of studies. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. COPD is a progressive disease which can cause obstruction of airflow in the lungs resulting in debilitating bouts of breathlessness . Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Before taking Fasenra, talk with your doctor about your health history. You should always consult your doctor or another healthcare professional before taking any medication. upper respiratory tract infections, abdominal pain, vomiting, diarrhoea, skin rashes, arthritis, muscle aches and joint pain. Make sure you tell your doctor if you have any other medical problems, especially: A doctor or other trained health professional will give you this medicine. They were then given Fasenra or a placebo (treatment with no active drug). You can also talk with your doctor or pharmacist to learn more about Fasenra and your other asthma medications. Drugs often used to treat asthma that may be used with Fasenra include: Talk with your doctor or pharmacist about which medications youll need to take with Fasenra. AstraZeneca, the manufacturer of Fasenra, has reimbursement counselors on staff who can discuss cost savings options with you. These lists contain examples of serious side effects that can occur with Fasenra, with Nucala, or with both drugs (when taken individually). After 4 weeks, the number of asthma exacerbations reduced. If youll give yourself Fasenra doses at home, your doctor will prescribe Fasenra pens to you. If you use this medicine at home, you will be shown the body areas where this shot can be given. * Xolair has a boxed warning for a severe allergic reaction called anaphylaxis. Activation of eosinophils can lead to the release of substances that promote inflammation. Half of the people in these studies took Fasenra and half took a placebo (treatment with no active drug). If you have asthma, your airways are swollen. If youre pregnant and have already taken Fasenra during your pregnancy, you may be able to join the Fasenra & Pregnancy Study. Fasenra may cause joint pain. These lists contain examples of more common side effects that can occur with Xolair, or with Fasenra and Xolair (when taken individually). With severe eosinophilic asthma, you have high levels of eosinophils in your body. Do not take more Fasenra than your doctor prescribes. In the last few years, a new group of prescription drugs has been introduced to treat severe asthma. The dose of this medicine will be different for different patients. Do not heat it in direct sunlight, the microwave, or in hot water because this will ruin the medicine. No, Fasenra isnt known to cause long-term side effects. But severe eosinophilic asthma typically requires treatment for some time before the condition improves. The more common side effects of Fasenra can include: If you have a headache or sore throat after taking Fasenra, the side effects will likely fade. If you have asthma, talk with your doctor about whether its safe for you to consume alcohol. Fasenra also shouldnt be used to treat other eosinophilic conditions. Check with your doctor on the best ways to treat asthma attacks and help prevent them. Your asthma symptoms can change over time, causing some medications to stop working effectively. With the prefilled autoinjector pen form, youll use the pen to give yourself injections after you receive training from a healthcare professional. You can also check out this article to learn more about saving money on prescriptions. Fasenra belongs to a class of drugs called interleukin-5 monoclonal antibodies. If you have a certain kind of asthma, your doctor may prescribe Fasenra. If you notice any other effects, check with your healthcare professional. This reduces inflammation and is thought to reduce asthma symptoms. Tell them about all prescription, over-the-counter, and other drugs you take. This date is typically 1 year from the date they dispensed the medication. Fasenra will not treat an asthma attack or exacerbations of asthma (acute bronchospasm or status asthmaticus). They can tell you about other medications that may work well for you. Fasenra isnt a steroid. Any woman that does become pregnant while being administered Fasenra should enroll in the pregnancy exposure registry by calling 1-877-311-8972 or visiting mothertobaby.org/Fasenra. Before leaving the office or clinic, make sure that you have an appointment for your next Fasenra injection scheduled. These factors include what your insurance plan covers and which pharmacy you use. Your doctor will tell you more about the other asthma medications youll take together with Fasenra. This helps prevent others, including children and pets, from taking the drug by accident. It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects. Off-label use is when a drug thats approved to treat one condition is prescribed to treat a different condition. But joint pain isn't typically a common side effect in people who take Dupixent for eczema or asthma.. But if you dont use the Fasenra pens within that time frame, you must dispose of them. As with most drugs, some people can have an allergic reaction after taking Fasenra. Once Fasenra is attached, it tells your immune system to destroy the eosinophils. Fasenra 30 mg/mL single-dose prefilled syringe (medicine). Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Must be given by subcutaneous injection, although people can be taught how to self-administer the Fasenra autoinjector. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. With eosinophilic asthma, you also experience high levels of eosinophils (a type of white blood cell). Dupixent belongs to a different class of drugs called interleukin-4 monoclonal antibodies. But in studies of the drug, this side effect wasn't common. Its available in two forms: Keep reading for information about Fasenra, including the drugs side effects, uses, and dosage, and more. By targeting this receptor, Fasenra promotes destruction of these cells via antibody-dependent cell-mediated cytotoxicity. Fasenra may not be right for you if you have certain medical conditions or other factors that affect your health. (Biosimilars are like generic drugs. If you have a parasitic infection, it should be treated before you start Fasenra. This type of pharmacy is authorized to carry specialty medications. Wash your hands and clean the injection site with an alcohol swab. In comparison, 6% of people who took a placebo had headaches. Keep in mind that side effects of a drug can depend on: Your doctor or pharmacist can tell you more about the potential side effects of Fasenra. Use a different body area each time you give yourself a shot. Do not keep outdated medicine or medicine no longer needed. According to research, about 10-25% of back pain experienced by adults is caused by sacroiliac joints. If you miss a dose of this medicine, take it as soon as possible. If you think you are gaining weight on Fasenra, keep a diary that documents your daily diet, amount of exercise, and daily weight gain. Fasenra is a humanized IgG1-kappa monoclonal antibody. In some cases, they may gradually reduce your corticosteroid dosage. They can review the benefits and possible risks of breastfeeding while using this drug. Do not freeze Fasenra pens or expose them to heat. Your insurance plan may require you to get prior authorization before approving coverage for Fasenra. What is Fasenra used for and how does it work? Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Will I take other medications for asthma together with Fasenra? Asthma is a condition that affects your airways, making them swollen. Asking questions can help you decide if the drug is a good treatment option for you. Fasenra does not replace your rescue inhaler, which is used to treat sudden asthma symptoms. But if you think youre having a medical emergency, call 911 or your local emergency number. If you use a corticosteroid medicine (inhaled or taken by mouth) to control your asthma, keep using it unless your doctor tells you otherwise. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Dupixent (dupilumab) is a brand-name prescription medication. When administered subcutaneously to patients with asthma, Fasenra has a bioavailability of 59%. Serious side effects from Fasenra arent common, but they can occur. Fasenra comes in two forms: a prefilled syringe and a prefilled autoinjector pen. Fasenra is a biologic drug, which is created from living cells. Many factors play a role in triggering asthma attacks. If you do have an asthma attack, Fasenra wont help treat your symptoms. Neither drug is a rescue inhaler. Then your dosage will change to one dose every 8 weeks. This reduces the number of eosinophils in your airways. It then sends signals to other cells in your body to destroy the eosinophils. But if you have severe symptoms, immediately call 911 or your local emergency number. There arent any known interactions between Fasenra and any drugs, herbs, foods, or supplements. The following information includes only the average doses of this medicine. To learn more about this side effect, see Allergic reaction just below. The early-morning news program offers the latest news, business, weather, and sports reports of the day, along with trending stories and new viral videos. This means that most people taking the drug will be prescribed the same dosage. If needed, you can keep Fasenra pens at a room temperature of up to 77F (25C) for as long as 14 days. One study didnt find that the drug lowered the risk of COPD flare-ups. It is given to patients whose asthma is not controlled with their current asthma medicines. Fasenra is not indicated for the treatment of other eosinophilic conditions such as eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) or hypereosinophilic syndrome (HES). Available for Android and iOS devices. 2023 Healthline Media UK Ltd, Brighton, UK. A clinical study looked at 1,204 people who had severe eosinophilic asthma and were using at least two medications to treat asthma. As a result, air cant move properly into and out of your lungs. Although not all of these side effects may occur, if they do occur they may need medical attention. (See the Dosage for asthma section right above.). You should refer to the prescribing information for Fasenra for any updates or newly noted interactions. These cells are part of your immune system. No. Throw away any medicine left out of the refrigerator for more than 14 days. 57. Fasenra should not be shaken, frozen, or exposed to heat. Managing Stress While Living With Asthma: Where Do I Even Start? Learn about how biologics treat severe asthma. Fasenra is prescribed using a standard dosage. Only inject into clear, healthy skin. Clinical trials of similar medications show that Fasenra may pass into breast milk. As with all medications, the cost of Fasenra can vary. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. Fasenra may be injected in different parts of your body such as your upper arms, thighs, or belly. Updated 01/2023. It also helps reduce blood eosinophils, which are a type of white blood cell that may contribute to your asthma. Allergic reaction, which is discussed in detail below, was the only serious side effect reported during clinical studies. IL-5 is the main cytokine responsible for the growth and differentiation, recruitment, activation, and survival of eosinophils. You might also be interested in how Fasenra compares with Dupixent. What should I know about Fasenra vs. Xolair? You may report them to the FDA. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. It reaches distribution volumes of 3.1 L (central) and 2.5 L (peripheral) in people weighing 154 pounds (which is about 70 kilograms). As a result, theres less inflammation (swelling), and you have a lower risk for asthma flare-ups. They can also include swelling of your tongue, mouth, or throat, which can cause trouble breathing. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. This is a decision you and your doctor will make. You may wonder how often certain side effects occur with this drug, or whether certain side effects pertain to it. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. People can be taught how to self-administer Fasenra. The Food and Drug Administration (FDA) approves prescription drugs such as Fasenra to treat certain conditions. Symptoms of an allergic reaction to Fasenra can include: Call your doctor right away if you have a severe allergic reaction to Fasenra. If youre interested in finding an alternative to Fasenra, talk with your doctor. All rights reserved. Fasenra is given as an injection under your skin (subcutaneous injection). If I have side effects from Fasenra, is there a lower dose I can try?
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