The liver damage never progressed to liver failure, and most cases were resolved within five months. 2013;2013:571420. View abstract. Ashwagandha has mild interactions with at least 29 different drugs. Certain ingredients can influence the effectiveness of your antidepressants and how they affect your health. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. 2014;20(12):901-908. doi:10.1089/acm.2014.0177, Remenapp A, Coyle K, Orange T, et al. Biomed Res Int 2015;2015:284154.View abstract. Withania somnifera extract. This product may interfere with some lab tests. However, some other statins do not seem to be affected by grapefruit juice, including pravastatin (Pravachol), fluvastatin (Lescol) and rosuvastatin (Crestor). J Atten Disord 2010;14:281-91. Phytomedicine 2000;7(6):463-469. People using ashwagandha for physical performance may need to take higher doses of up to 1,250 milligrams daily to see benefits. Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. View abstract. What are some herbs that are contraindicated with Cotellic (cobimetinib)? 2020;34(5):1041-1059. Withania somnifera, known as ashwagandha, has a role in ayurvedic medicine for a wide range of health conditions. Indian J Med Res 2015 Jan;141(1):100-6. 2008;6:14. Evid Based Complement Alternat Med. Speak with a, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Mediterranean, Low-Fat Diets Are Best for Heart Problems, Least Amount of Exercise You Need to Stay Healthy, Nerve 'Pulse' Therapy May Help Ease Sciatica, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Attention deficit-hyperactivity disorder (ADHD), Chronic obstructive pulmonary disease (COPD), Antipsychotic-induced metabolic side effects, Think Your Child Has ADHD? Information from this source is evidence-based and objective, and without commercial influence. These are: In addition to these commonly prescribed antidepressants, there are other central nervous system drugs with antidepressant effects, like antipsychotics, as well as herbs and supplements that have natural antidepressant properties. J Altern Complement Med. View abstract. Ashwagandha may have additive effects to certain drugs that are used for diabetes, high blood pressure, and low thyroid hormone, to name a few. Mild Interactions of hydroxyzine include: ashwagandha; brimonidine; eucalyptus; nettle; sage; siberian ginseng; This information does not contain all possible interactions or adverse effects. View abstract. In 2020 and 2021, some people began using ashwagandha to diminish the harmful effects of COVID-19, although there is no evidence to support that use. You can mix other nonessential amino acids and antidepressants without any issues. Certain antidepressants may not be compatible with herbs or other natural ingredients in these products. Examples of immunosuppressants include azathioprine, cyclosporine, mycophenolate, prednisone and corticosteroids. Chronic stress increases cortisol levels, leading to lower levels of T3 and T4. Other essential vitamins and minerals may also be helpful in treating depression. St. John's wort can cause a buildup of serotonin in the body when taken with antidepressants. The herb has been proven to interact with many other drugs, the interaction with SSRI (selective serotonin reuptake inhibitor) or Benzodiazepines are not proven scientifically. Efficacy of Withania somnifera supplementation on adult's cognition and mood. Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: a randomized controlled trial. Kaur, K., Rani, G., Widodo, N., Nagpal, A., Taira, K., Kaul, S. C., and Wadhwa, R. Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha. Bjrnsson HK, Bjrnsson ES, Avula B, et al. The comparative effect of milk fortified with Aswagandha, Aswagandha and Punarnava in children - a double-blind study. Naturopathic care for anxiety: a randomized controlled trial ISRC TN78958974. Some evidence suggests that ashwagandha may interact with: Before starting a new supplement, it is vital that you carefully read the ingredients list and nutrition facts panel to know which ingredients and how much of each ingredient is included in the supplement. Significant improvements were seen in all sleep parameters for those who took ashwagandha (300 milligrams twice daily). A study compared ashwagandha to a placebo to determine whether the herb would have a positive effect on insomnia. Tohda, C. [Overcoming several neurodegenerative diseases by traditional medicines: the development of therapeutic medicines and unraveling pathophysiological mechanisms]. Durg S, Bavage S, Shivaram SB. All rights reserved. After eight weeks, statistically significant improvements were seen in both aerobic capacity and recovery for those who took ashwagandha. Cent.Nerv.Syst.Agents Med.Chem. Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Researchers from another review concluded that ashwagandha might be useful in conditions such as: Studies used in this review included human, animal, and lab research. The combination could decrease the effectiveness of these medications. Drug Metabol.Drug Interact. There are no vitamins contraindicated for consumption with antidepressants, but you should be cautious about consuming a mixture of supplements. Fuladi S, Emami SA, Mohammadpour AH, Karimani A, Manteghi AA, Sahebkar A. 8-19-2005;334(1):276-287. Suryawanshi G, Abdallah M, Thomson M, Desai N, Chauhan A, Lim N. Ashwagandha-Associated Acute Liver Failure Requiring Liver Transplantation. According to the Mayo Clinic, all of these SSRIs work by blocking the reuptake of serotonin in the brain, which essentially makes serotonin more available. The specific components of physical performance included strength and power, endurance, and fatigue/recovery. 2003;19(3):211-222. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. View abstract. When possible, choose a supplement tested by a trusted third party, such as U.S. Pharmacopeia (USP), ConsumerLab, or NSF. Be sure to confirm new supplements fit your dietary needs or preferences. In our latest question and answer, the pharmacist discusses whether or not ashwagandha supplements interact with prescription drugs. Phytotherapy Research 1991;5:111-114. Curr Clin Pharmacol. Does Ashwagandha Interact With Any Medications? View abstract. Deshpande A, Irani N, Balkrishnan R, Benny IR. Cancer Lett 2000;148:9-17. You will need to talk about the benefits and risks of using this natural product. The roots can be used topically as a poult. The drug interactions listed above are not all of the possible interactions or adverse effects. This herbal medicine term means that this substance is thought to help the body respond to mental and physical stress and to restore normal emotional and physical body function. Studies are inconclusive, but ashwagandha may have immune-stimulating properties. Ashwaganda is used to treat Herbal Supplementation. Agarwal R, Diwanay S, Patki P, Patwardhan B. No, that's not true all the time. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat. In this randomized, double-blind, placebo-controlled trial, 125 adult participants were randomized to either 300 milligrams per day of ashwagandha sustained release or a placebo for 90 days. For most people, ashwagandha is a safe and effective supplement for taking the edge off stress. 2009;15(4):423-430. Ashwagandha may increase thyroid hormone levels. 2021;57:102642. doi:10.1016/j.ctim.2020.102642, Bjrnsson HK, Bjrnsson ES, Avula B, et al. 2017;10(3):96-100. doi:10.5935/1984-0063.20170018. One systematic review found just five human trials that studied ashwagandha as an anxiety treatment. ", Mayo Clinic: "Selective Serotonin Reuptake Inhibitors (SSRIs)", Cleveland Clinic: "Depression Medicines: Risks / Benefits", Shanghai Archives of Psychiatry: "Use of Antipsychotics in the Treatment of Depressive Disorders", Food and Drug Administration: "Vitamins and Minerals Chart", World Journal of Biological Chemistry: "Complexity of Vitamin E Metabolism", NCBI Bookshelf: "Depression in Adults With a Chronic Physical Health Problem: Treatment and Management", Journal of Medicine and Life: "Nutrition and Depression at the Forefront of Progress", Harvard Health Publishing: "Cytochrome P450 Enzymes and Psychiatric Drugs", Complementary Therapies in Medicine Journal: "Evaluation of the Efficacy of Withania Somnifera (Ashwagandha) Root Extract in Patients With Obsessive-Compulsive Disorder: A Randomized Double-Blind Placebo-Controlled Trial", Serotonin and norepinephrine reuptake inhibitors (SNRIs), Norepinephrine and dopamine reuptake inhibitors (NDRIs), Noncompetitive N-methyl-D-aspartate receptor antagonists. Singh P, Salman KA, Shameem M, Warsi MS. Withania somnifera (L.) Dunal as add-on therapy for COPD patients: a randomized, placebo-controlled, double-blind study. There are a variety of vitamins and minerals that are essential for good health. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Monitor your blood pressure closely. View abstract. Immunopharmacol.Immunotoxicol. 2021;16(9):e0257843. PLoS.One. Anyone with upcoming surgery should stop using ashwagandha at least two weeks prior. J Clin Psychiatry. It is commonly used for stress. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. This article provides a review of the potential uses of ashwagandha. No supplement is intended to treat, cure, or prevent disease. In Ayurvedic medicine, ashwagandha has been used for centuries as an alternative treatment for anxiety. Sud Khyati S, Thaker B. 2011;68(1):3-8. Usually ashwagandha is taken 1000 mg per day, for the course of 3 to 4 months. Ashwagandha is native to India and Southeast Asia and is one of the most important herbs in Ayurveda, an alternative natural system of medicine that originated in Indian over 3,000 years ago. Can You Take Lyrica And Flexeril Together? ashwagandha and guggul used for thyroid conditions and find out if they are beneficial. 2012;7(9):e44419. Be sure to talk with your doctor about this and all drugs you are taking, especially digoxin. 2021;6(1):20. doi:10.3390/jfmk6010020, Langade D, Kanchi S, Salve J, Debnath K, Ambegaokar D. Efficacy and safety of ashwagandha (Withania somnifera) root extract in insomnia and anxiety: a double-blind, randomized, placebo-controlled study. For insomnia, a dose of 600 milligrams per day has been found to be safe and effective. 2022;15(9):1067-1080. doi:10.1080/17512433.2022.2121699, Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Some people should avoid using ashwagandha due to safety concerns. The ashwagandha root extract has been used for thousands of years as an herbal remedy in Ayurveda, the ancient Indian medical system. Always check with your doctor before you use a natural product. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. View abstract. This interference is likely due to a similarity in chemical structure, according to Drugs.com. Jahanbakhsh SP, Manteghi AA, Emami SA, Mahyari S, et al. Doses higher than that may interact with lexapro, or produce more pronounced effects. Brain Behav. Typically, ashwagandha does not need to be refrigerated, but you should follow any storage directions provided by the supplement brand. According to an April 2016 review in the Journal of Psychiatry, several nutrients are involved in healthy brain activity. Journal of Research in Ayurveda and Siddha 1980;1(2):247-258. View abstract. Nutrients. Kuppurajan K, Rajagopalan SS, Sitoraman R, and et al. Venkataraghavan S, Seshadri C, Sundaresan TP, and et al. Dosage: How Much Ashwagandha Should I Take? At the end of the study, significant improvements in general memory and immediate memory were seen in the ashwagandha group. Devi, P. U., Sharada, A. C., Solomon, F. E., and Kamath, M. S. In vivo growth inhibitory effect of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma 180. Neurol India 2009;57:166-71. Prez-Gmez J, Villafaina S, Adsuar JC, Merellano-Navarro E, Collado-Mateo D. Effects of ashwagandha (Withania somnifera) on VO2max: A systematic review and meta-analysis. Study participants were randomized to receive a placebo, 225 milligrams per day of ashwagandha, or 400 milligrams per day of ashwagandha for 30 days. O'Connor J, Lindsay K, Baker C, Kirby J, Hutchins A, Harris M. The impact of ashwagandha on stress, sleep quality, and food cravings in college students: quantitative analysis of a double-blind randomized control trial. View abstract. According to their lab study, withanone may interfere with DNA, leading to liver damage. These are drugs like diazepam, lorazepam, phenobarbital, or zolpidem. Pusec CM, Wolsky R, Llerena C, Sura P. A Case of Supplement-Induced Hepatitis. Indian J Pharmacol. Tumori 8-31-1994;80(4):306-308. Of the 58 participants in the study, those who took ashwagandha had reduced levels of cortisol (a stress hormone) as well as lower perceived stress scores by the end of the eight-week study. Complement Ther Med. Bhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. 1988;26(11):877-882. If you take thyroid medicine, consult your doctor before using ashwagandha. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Ashwagandha may interact with various medications. View abstract. Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Headache. Holistic Medicine 42 years experience. No, Ashwagandha does not possess any qualities that cause it to be habit forming, and the risk of forming an addiction to Ashwagandha is little to none. For more information on drug interactions, visit the RxList Drug Interaction Checker. doi:10.7759/cureus.6466, Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: a randomized, double-blind, placebo-controlled study. 2013;45(4):417-8. Therefore,it could theoretically increase the risk of hypoglycemia (i.e. In large amounts, any of these could potentially affect the way your body processes antidepressants. J.Altern.Complement Med. Varying levels of research have looked at the potential benefits of ashwagandha. Select a condition to view a list of vitamins. Mikolai, J., Erlandsen, A., Murison, A., Brown, K. A., Gregory, W. L., Raman-Caplan, P., and Zwickey, H. L. In vivo effects of Ashwagandha (Withania somnifera) extract on the activation of lymphocytes. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Ashwagandha's leaves contain a compound that causes sleep induction and is used for treating insomnia. Copyright 2023 UpToDate, Inc. and its affiliates and/or licensors. Phytother Res 2022. However, the review noted various limitations of the studies, including study design and potential bias. Available for Android and iOS devices. hydrochlorothiazide, spironolactone, chlorthalidone). When taken inappropriately, ashwagandha can have side effects and potentially serious medicinal interactions. Investigation of CYP2B6, 3A4 and -esterase interactions of Withania somnifera (L.) dunal in human liver microsomes and HepG2 cells. Taking ashwagandha along with these medications might decrease the effects of these medications. Nat.Prod.Res 2005;19(6):567-571. In recent years, some researchers have assessed how ashwagandha may benefit physical performance. View abstract. They also are not very good drugs, because they have multiple potentially . Is It Safe To Take Keflex (Cephalexin) With Birth Control? According to the NIH, ashwagandha may interact with certain prescription medications, including antidiabetes drugs, antihypertensive drugs, immunosuppressants, benzodiazepines, certain sedative . Cureus. In rare cases, the use of ashwagandha may lead to liver damage. This includes: As with many other herbs and supplements, ashwagandha has a risk of side effects. Ashwagandha may help the body cope with stress. It is commonly used for stress. Ashwagandha May Interact With Certain Drugs. Indian J Exp Biol. Does Ashwagandha Interact With Any Medications? Indian J Exp Biol 1997;35:236-9. blood glucose). Dhuley, J. N. Therapeutic efficacy of Ashwagandha against experimental aspergillosis in mice. As a general rule of thumb, never exceed the recommended dose of ashwagandha. Kumar G, Srivastava A, Sharma SK, Rao TD, Gupta YK. J Med Food 2022. 2019;98(37):e17186. J Diet Suppl. Supplements That Are Similar to Ashwagandha. Ashwagandha may be able to help with insomnia. Acta Oncol. Sriranjini SJ, Pal PK, Devidas KV, Ganpathy S. Improvement of balance in progressive degenerative cerebellar ataxias after Ayurvedic therapy: a preliminary report. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Ashwagandha-induced liver injury: a case series from Iceland and the US Drug-Induced Liver Injury Network. Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. Answered by Dr. Brian Staiger, PharmD Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. J Ethnopharmacol 1999;67:233-39. Antioxidants (Basel). Take extra care if you are taking iron supplements. Last updated on Feb 3, 2023. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. This information may not fit your specific health circumstances. Gupta, S. K., Dua, A., and Vohra, B. P. Withania somnifera (Ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and protein oxidative modifications. Association of l-DOPA with recovery following Ayurveda medication in Parkinson's Disease. Expert Rev Clin Pharmacol. Melissa Nieves, LND, RD, is a registered dietitian and licensed nutritionist who works as a bilingual telehealth dietitian. The best time to take ashwagandha is at the time that works best for you. Effect of Indian Ayurvedic medicine Ashwagandha on measurement of serum digoxin and 11 commonly monitored drugs using immunoassays: study of protein binding and interaction with Digibind. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. View abstract. Bhattacharya, S. K. and Muruganandam, A. V. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Complement Ther Med 2016 Aug;27:25-9.View abstract. 2021 Feb 11;6(1):20. doi: 10.3390/jfmk6010020. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. and treatment options, including any risks or benefits regarding use of medications. V. The effect of total alkaloids (ashwagandholine) on the central nervous system. Who Shouldn't Take Ashwagandha? Take extra care and check with your doctor if you have: Signs of a very bad reaction. Xanax is used to treat the following conditions: Anxiety; Panic Disorder; Drug and food interactions
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